Sugar-sweetened beverage (SSB) consumption begins early and increases with age in the U.S., and there is robust evidence linking SSB consumption with negative health consequences. This systematic review synthesizes evidence from 27 studies on strategies aimed to reduce SSB consumption among 0- to 5-year-olds. Interventions took place primarily in healthcare settings, as well as preschool/daycare, home, community venues, and other settings. Overarching strategies which successfully reduced SSB consumption included: (i) in-person individual education; (ii) in-person group education; (iii) passive education (e.g. pamphlets); (iv) use of technology; (v) training for childcare/healthcare providers; and (vi) changes to the physical access of beverages. Overall, evidence suggests that interventions successful at reducing SSB consumption among 0- to 5-year-olds often focused on vulnerable populations, were conducted in preschool/daycare settings, specifically targeted only SSBs or only oral hygiene, included multiple intervention strategies, and had higher intervention intensity/contact time.